Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM62156
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
8890±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM62156
Synonyms:
5-Nitro-furan-2-carboxylic acid [2-(4-isobutyryl-piperazin-1-yl)-phenyl]-amide | MLS001223269 | N-[2-(4-isobutyrylpiperazino)phenyl]-5-nitro-2-furamide | N-[2-[4-(2-methyl-1-oxopropyl)-1-piperazinyl]phenyl]-5-nitro-2-furancarboxamide | N-[2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]-5-nitro-furan-2-carboxamide | N-[2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]-5-nitrofuran-2-carboxamide | SMR000612696 | cid_1091600
Type:
Small organic molecule
Emp. Form.:
C19H22N4O5
Mol. Mass.:
386.4018
SMILES:
CC(C)C(=O)N1CCN(CC1)c1ccccc1NC(=O)c1ccc(o1)[N+]([O-])=O
Structure:
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