Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78431
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
7950±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78431
Synonyms:
2-(2-methylphenoxy)-N-(4-pyrrolidin-1-ylsulfonylphenyl)acetamide | 2-(2-methylphenoxy)-N-(4-pyrrolidin-1-ylsulfonylphenyl)ethanamide | 2-(2-methylphenoxy)-N-(4-pyrrolidinosulfonylphenyl)acetamide | 2-(2-methylphenoxy)-N-[4-(1-pyrrolidinylsulfonyl)phenyl]acetamide | MLS001138651 | SMR000712839 | cid_1010790
Type:
Small organic molecule
Emp. Form.:
C19H22N2O4S
Mol. Mass.:
374.454
SMILES:
Cc1ccccc1OCC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC1
Structure:
Search PDB for entries with ligand similarity: