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Target
Neurotensin receptor type 1
Ligand
BDBM57070
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1
EC50
26000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 PubChem Bioassay (2011)[AID] 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM57070
Synonyms:
4,6-bis(3,5-dimethyl-1-pyrazolyl)-N-[2-(trifluoromethyl)phenyl]-1,3,5-triazin-2-amine | 4,6-bis(3,5-dimethylpyrazol-1-yl)-N-[2-(trifluoromethyl)phenyl]-1,3,5-triazin-2-amine | MLS000527413 | SMR000117887 | [4,6-Bis-(3,5-dimethyl-pyrazol-1-yl)-[1,3,5]triazin-2-yl]-(2-trifluoromethyl-phenyl)-amine | [4,6-bis(3,5-dimethylpyrazol-1-yl)-s-triazin-2-yl]-[2-(trifluoromethyl)phenyl]amine | cid_634713
Type:
Small organic molecule
Emp. Form.:
C20H19F3N8
Mol. Mass.:
428.4137
SMILES:
Cc1cc(C)n(n1)-c1nc(Nc2ccccc2C(F)(F)F)nc(n1)-n1nc(C)cc1C
Structure:
Search PDB for entries with ligand similarity: