Reaction Details Report a problem with these data
Target
Protein Mdm4
Ligand
BDBM63209
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format
IC50
3.74±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format PubChem Bioassay (2011)[AID] 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM63209
Synonyms:
3-(1-phenyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-2H-chromen-2-one | 3-(1-phenyl-2-thioxo-4-imidazolin-4-yl)coumarin | 3-(3-phenyl-2-sulfanylidene-1H-imidazol-5-yl)-1-benzopyran-2-one | 3-(3-phenyl-2-sulfanylidene-1H-imidazol-5-yl)chromen-2-one | CHEMBL1352521 | MLS000583508 | SMR000206694 | cid_3380837
Type:
Small organic molecule
Emp. Form.:
C18H12N2O2S
Mol. Mass.:
320.365
SMILES:
O=c1oc2ccccc2cc1-c1cn(-c2ccccc2)c(=S)[nH]1
Structure:
Search PDB for entries with ligand similarity: