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Target
Protein Mdm4
Ligand
BDBM65180
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format
IC50
2680±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format PubChem Bioassay (2011)[AID] 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM65180
Synonyms:
(3,4-Dihydro-2H-quinolin-1-yl)-acetic acid [1-(2-hydroxy-naphthalen-1-yl)-meth-(E)-ylidene]-hydrazide | 2-(3,4-dihydro-2H-quinolin-1-yl)-N'-[(Z)-(2-keto-1-naphthylidene)methyl]acetohydrazide | 2-(3,4-dihydro-2H-quinolin-1-yl)-N'-[(Z)-(2-oxidanylidenenaphthalen-1-ylidene)methyl]ethanehydrazide | 2-(3,4-dihydro-2H-quinolin-1-yl)-N'-[(Z)-(2-oxo-1-naphthalenylidene)methyl]acetohydrazide | 2-(3,4-dihydro-2H-quinolin-1-yl)-N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]acetohydrazide | MLS000590824 | SMR000217718 | cid_6842960
Type:
Small organic molecule
Emp. Form.:
C22H21N3O2
Mol. Mass.:
359.421
SMILES:
Oc1ccc2ccccc2c1C=NNC(=O)CN1CCCc2ccccc12 |w:12.14|
Structure:
Search PDB for entries with ligand similarity: