Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77672
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77672
Synonyms:
MLS000102881 | N-(4-tert-butyl-1,3-thiazol-2-yl)-5-chloranyl-thiophene-2-carboxamide | N-(4-tert-butyl-1,3-thiazol-2-yl)-5-chlorothiophene-2-carboxamide | N-(4-tert-butyl-2-thiazolyl)-5-chloro-2-thiophenecarboxamide | N-(4-tert-butylthiazol-2-yl)-5-chloro-thiophene-2-carboxamide | SMR000017402 | cid_1247280
Type:
Small organic molecule
Emp. Form.:
C12H13ClN2OS2
Mol. Mass.:
300.827
SMILES:
CC(C)(C)c1csc(NC(=O)c2ccc(Cl)s2)n1
Structure:
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