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Target
BRCA1-associated RING domain protein 1
Ligand
BDBM48281
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay
IC50
493±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay PubChem Bioassay (2011)[AID] 
Target
Name:
BRCA1-associated RING domain protein 1
Synonyms:
BARD-1 | BARD1 | BARD1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
86678.08
Organism:
Homo sapiens (Human)
Description:
gi_116241265
Residue:
777
Sequence:
MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
  
Inhibitor
Name:
BDBM48281
Synonyms:
(2-fluorophenyl)-[5-[1-(2-methoxyethyl)-2,5-dimethyl-pyrrol-3-yl]-6H-1,3,4-thiadiazin-2-yl]amine | MLS000564266 | N-(2-fluorophenyl)-5-[1-(2-methoxyethyl)-2,5-dimethyl-3-pyrrolyl]-6H-1,3,4-thiadiazin-2-amine | N-(2-fluorophenyl)-5-[1-(2-methoxyethyl)-2,5-dimethyl-pyrrol-3-yl]-6H-1,3,4-thiadiazin-2-amine | N-(2-fluorophenyl)-5-[1-(2-methoxyethyl)-2,5-dimethylpyrrol-3-yl]-6H-1,3,4-thiadiazin-2-amine | SMR000151762 | cid_3606829
Type:
Small organic molecule
Emp. Form.:
C18H21FN4OS
Mol. Mass.:
360.449
SMILES:
COCCn1c(C)cc(c1C)C1=NN=C(Nc2ccccc2F)SC1 |t:12,14|
Structure:
Search PDB for entries with ligand similarity: