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Target
BRCA1-associated RING domain protein 1
Ligand
BDBM79633
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay
IC50
8390±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay PubChem Bioassay (2011)[AID] 
Target
Name:
BRCA1-associated RING domain protein 1
Synonyms:
BARD-1 | BARD1 | BARD1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
86678.08
Organism:
Homo sapiens (Human)
Description:
gi_116241265
Residue:
777
Sequence:
MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
  
Inhibitor
Name:
BDBM79633
Synonyms:
4-[2-(4,5-dichloro-6-keto-pyridazin-1-yl)acetyl]-3,3-dimethyl-1H-quinoxalin-2-one | 4-[2-(4,5-dichloro-6-oxo-1-pyridazinyl)-1-oxoethyl]-3,3-dimethyl-1H-quinoxalin-2-one | 4-[2-(4,5-dichloro-6-oxopyridazin-1-yl)acetyl]-3,3-dimethyl-1H-quinoxalin-2-one | 4-[2-[4,5-bis(chloranyl)-6-oxidanylidene-pyridazin-1-yl]ethanoyl]-3,3-dimethyl-1H-quinoxalin-2-one | MLS000770735 | SMR000343943 | cid_2539138
Type:
Small organic molecule
Emp. Form.:
C16H14Cl2N4O3
Mol. Mass.:
381.213
SMILES:
CC1(C)N(C(=O)Cn2ncc(Cl)c(Cl)c2=O)c2ccccc2NC1=O
Structure:
Search PDB for entries with ligand similarity: