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Target
BRCA1-associated RING domain protein 1
Ligand
BDBM79636
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay
IC50
4130±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay PubChem Bioassay (2011)[AID] 
Target
Name:
BRCA1-associated RING domain protein 1
Synonyms:
BARD-1 | BARD1 | BARD1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
86678.08
Organism:
Homo sapiens (Human)
Description:
gi_116241265
Residue:
777
Sequence:
MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
  
Inhibitor
Name:
BDBM79636
Synonyms:
1-(2-furanylmethyl)-2-imino-10-methyl-5-oxo-N-(2-phenylethyl)-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide | 1-(2-furfuryl)-2-imino-5-keto-10-methyl-N-phenethyl-dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide | 1-(furan-2-ylmethyl)-2-imino-10-methyl-5-oxo-N-(2-phenylethyl)dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide | 1-Furan-2-ylmethyl-2-imino-8-methyl-10-oxo-1,10-dihydro-2H-1,9,10a-triaza-anthracene-3-carboxylic acid phenethyl-amide | 2-azanylidene-1-(furan-2-ylmethyl)-10-methyl-5-oxidanylidene-N-(2-phenylethyl)dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide | MLS001221279 | SMR000612014 | cid_1077343
Type:
Small organic molecule
Emp. Form.:
C26H23N5O3
Mol. Mass.:
453.4925
SMILES:
Cc1cccn2c1nc1n(Cc3ccco3)c(=N)c(cc1c2=O)C(=O)NCCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: