Reaction Details Report a problem with these data
Target
Tropomyosin alpha-1 chain
Ligand
BDBM79665
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
2780±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM79665
Synonyms:
2-[4-(diethylamino)-2-hydroxy-benzylidene]thiazolo[3,2-a]benzimidazol-1-one | 2-[4-(diethylamino)-2-hydroxybenzylidene][1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one | 2-[[4-(diethylamino)-2-hydroxyphenyl]methylidene]-1-thiazolo[3,2-a]benzimidazolone | 2-[[4-(diethylamino)-2-hydroxyphenyl]methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one | 2-[[4-(diethylamino)-2-oxidanyl-phenyl]methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one | MLS000549987 | SMR000113390 | cid_612337
Type:
Small organic molecule
Emp. Form.:
C20H19N3O2S
Mol. Mass.:
365.449
SMILES:
CCN(CC)c1ccc(C=c2sc3nc4ccccc4n3c2=O)c(O)c1
Structure:
Search PDB for entries with ligand similarity: