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Target
Tropomyosin alpha-1 chain
Ligand
BDBM79715
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
>71480±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM79715
Synonyms:
(cyclobutylmethyl){[3-(2,4-difluorophenyl)-1H-pyrazol-4-yl]methyl}(tetrahydrofuran-2-ylmethyl)amine | 1-cyclobutyl-N-[[5-(2,4-difluorophenyl)-1H-pyrazol-4-yl]methyl]-N-(2-oxolanylmethyl)methanamine | 1-cyclobutyl-N-[[5-(2,4-difluorophenyl)-1H-pyrazol-4-yl]methyl]-N-(oxolan-2-ylmethyl)methanamine | MLS000731688 | N-[[5-[2,4-bis(fluoranyl)phenyl]-1H-pyrazol-4-yl]methyl]-1-cyclobutyl-N-(oxolan-2-ylmethyl)methanamine | SMR000315735 | cid_16189956 | cyclobutylmethyl-[[5-(2,4-difluorophenyl)-1H-pyrazol-4-yl]methyl]-(tetrahydrofurfuryl)amine
Type:
Small organic molecule
Emp. Form.:
C20H25F2N3O
Mol. Mass.:
361.4288
SMILES:
Fc1ccc(-c2n[nH]cc2CN(CC2CCC2)CC2CCCO2)c(F)c1
Structure:
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