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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM48553
Substrate
n/a
Meas. Tech.
Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1)
IC50
1974±n/a nM
Citation
 PubChem, PC Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) PubChem Bioassay (2011)[AID] 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM48553
Synonyms:
5-(1,3-benzothiazol-2-yl)-N-(5-methyl-1,3-thiazol-2-yl)furan-2-carboxamide | 5-(1,3-benzothiazol-2-yl)-N-(5-methyl-2-thiazolyl)-2-furancarboxamide | 5-(1,3-benzothiazol-2-yl)-N-(5-methylthiazol-2-yl)-2-furamide | MLS000056472 | SMR000067829 | cid_2555366
Type:
Small organic molecule
Emp. Form.:
C16H11N3O2S2
Mol. Mass.:
341.407
SMILES:
Cc1cnc(NC(=O)c2ccc(o2)-c2nc3ccccc3s2)s1
Structure:
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