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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM79907
Substrate
n/a
Meas. Tech.
Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1)
IC50
>49771±n/a nM
Citation
 PubChem, PC Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) PubChem Bioassay (2011)[AID] 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM79907
Synonyms:
5-(2-Chloro-phenyl)-isoxazole-3-carboxylic acid (2-hydroxy-5-methyl-phenyl)-amide | 5-(2-chlorophenyl)-N-(2-hydroxy-5-methyl-phenyl)isoxazole-3-carboxamide | 5-(2-chlorophenyl)-N-(2-hydroxy-5-methylphenyl)-1,2-oxazole-3-carboxamide | 5-(2-chlorophenyl)-N-(2-hydroxy-5-methylphenyl)-3-isoxazolecarboxamide | 5-(2-chlorophenyl)-N-(5-methyl-2-oxidanyl-phenyl)-1,2-oxazole-3-carboxamide | MLS001202480 | SMR000524508 | cid_1093851
Type:
Small organic molecule
Emp. Form.:
C17H13ClN2O3
Mol. Mass.:
328.75
SMILES:
Cc1ccc(O)c(NC(=O)c2cc(on2)-c2ccccc2Cl)c1
Structure:
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