Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80115
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen
Temperature
298.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80115
Synonyms:
2-[(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methylsulfanyl]-1H-quinazolin-4-one | 2-[(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methylthio]-1H-quinazolin-4-one | 2-[(4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)methylthio]-1H-quinazolin-4-one | 2-{[(4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]thio}-4(3H)-quinazolinone | MLS000052560 | SMR000082057 | cid_1256582
Type:
Small organic molecule
Emp. Form.:
C17H13N5OS2
Mol. Mass.:
367.448
SMILES:
O=c1[nH]c(SCc2n[nH]c(=S)n2-c2ccccc2)nc2ccccc12
Structure:
