Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80345
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen
Temperature
298.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80345
Synonyms:
4-(2-methylpropyl)-3-(3-morpholin-4-ylsulfonylphenyl)-1H-1,2,4-triazole-5-thione | 4-(2-methylpropyl)-3-[3-(4-morpholinylsulfonyl)phenyl]-1H-1,2,4-triazole-5-thione | 4-isobutyl-3-(3-morpholinosulfonylphenyl)-1H-1,2,4-triazole-5-thione | MLS002252390 | SMR001314737 | cid_2375957
Type:
Small organic molecule
Emp. Form.:
C16H22N4O3S2
Mol. Mass.:
382.501
SMILES:
CC(C)Cn1c(n[nH]c1=S)-c1cccc(c1)S(=O)(=O)N1CCOCC1
Structure:
