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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80544
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
1650±158 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80544
Synonyms:
2-(6-Chloro-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-N-(3-methyl-pyridin-2-yl)-acetamide | 2-(6-chloranyl-3-oxidanylidene-1,4-benzoxazin-4-yl)-N-(3-methylpyridin-2-yl)ethanamide | 2-(6-chloro-3-keto-1,4-benzoxazin-4-yl)-N-(3-methyl-2-pyridyl)acetamide | 2-(6-chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(3-methyl-2-pyridinyl)acetamide | 2-(6-chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(3-methylpyridin-2-yl)acetamide | MLS001203248 | SMR000525195 | cid_6473547
Type:
Small organic molecule
Emp. Form.:
C16H14ClN3O3
Mol. Mass.:
331.754
SMILES:
Cc1cccnc1NC(=O)CN1C(=O)COc2ccc(Cl)cc12
Structure:
