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Target
Egl nine homolog 1
Ligand
BDBM141561
Substrate
n/a
Meas. Tech.
HIF-PH Assay
pH
7.4±n/a
IC50
90±n/a nM
Comments
extracted
Citation
 Ng, D; Arend, MP; Flippin, LA Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase US Patent  US9695170 Publication Date 7/4/2017 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM141561
Synonyms:
US8921389, 17 | US9695170 17
Type:
Small organic molecule
Emp. Form.:
C26H20N4O5
Mol. Mass.:
468.4608
SMILES:
OC(=O)CNC(=O)c1nc(C#N)c2n(Cc3ccccc3)c(=O)c(Cc3ccccc3)cc2c1O
Structure:
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