Reaction Details Report a problem with these data
Target
DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM48462
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
13600±n/a nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
  
Inhibitor
Name:
BDBM48462
Synonyms:
2-(2-furanyl)-N-hexyl-4-quinolinecarboxamide | 2-(2-furyl)-N-hexyl-4-quinolinecarboxamide | 2-(2-furyl)-N-hexyl-cinchoninamide | 2-(furan-2-yl)-N-hexyl-quinoline-4-carboxamide | 2-(furan-2-yl)-N-hexylquinoline-4-carboxamide | MLS000550438 | SMR000114759 | cid_1742630
Type:
Small organic molecule
Emp. Form.:
C20H22N2O2
Mol. Mass.:
322.4009
SMILES:
CCCCCCNC(=O)c1cc(nc2ccccc12)-c1ccco1
Structure:
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