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Target
Cysteine protease ATG4B
Ligand
BDBM39704
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50
5440±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM39704
Synonyms:
(3-methyl-4-propan-2-yl-phenyl) thiophene-2-carboxylate | (3-methyl-4-propan-2-ylphenyl) thiophene-2-carboxylate | 2-thiophenecarboxylic acid (3-methyl-4-propan-2-ylphenyl) ester | 4-isopropyl-3-methylphenyl 2-thiophenecarboxylate | MLS000533631 | SMR000141069 | cid_881438 | thiophene-2-carboxylic acid (4-isopropyl-3-methyl-phenyl) ester
Type:
Small organic molecule
Emp. Form.:
C15H16O2S
Mol. Mass.:
260.351
SMILES:
CC(C)c1ccc(OC(=O)c2cccs2)cc1C
Structure:
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