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Target
Cysteine protease ATG4B
Ligand
BDBM80889
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50
4380±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM80889
Synonyms:
2-(3,5-dimethoxyphenyl)-3-[(3,4-dimethylbenzoyl)oxy]quinazolin-4(3H)-one | 3,4-dimethylbenzoic acid [2-(3,5-dimethoxyphenyl)-4-keto-quinazolin-3-yl] ester | 3,4-dimethylbenzoic acid [2-(3,5-dimethoxyphenyl)-4-oxo-3-quinazolinyl] ester | MLS000584739 | SMR000203702 | [2-(3,5-dimethoxyphenyl)-4-oxidanylidene-quinazolin-3-yl] 3,4-dimethylbenzoate | [2-(3,5-dimethoxyphenyl)-4-oxoquinazolin-3-yl] 3,4-dimethylbenzoate | cid_12004875
Type:
Small organic molecule
Emp. Form.:
C25H22N2O5
Mol. Mass.:
430.4526
SMILES:
COc1cc(OC)cc(c1)-c1nc2ccccc2c(=O)n1OC(=O)c1ccc(C)c(C)c1
Structure:
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