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Target
Cysteine protease ATG4B
Ligand
BDBM54372
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50
4240±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM54372
Synonyms:
(5Z)-5-[(6-methoxy-2-piperidin-1-yl-quinolin-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | (5Z)-5-[(6-methoxy-2-piperidin-1-ylquinolin-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | (5Z)-5-[(6-methoxy-2-piperidino-3-quinolyl)methylene]-2-thioxo-thiazolidin-4-one | (5Z)-5-[[6-methoxy-2-(1-piperidinyl)-3-quinolinyl]methylidene]-2-sulfanylidene-4-thiazolidinone | 5-[1-(6-Methoxy-2-piperidin-1-yl-quinolin-3-yl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one | MLS001047279 | SMR000427674 | cid_1385343
Type:
Small organic molecule
Emp. Form.:
C19H19N3O2S2
Mol. Mass.:
385.503
SMILES:
COc1ccc2nc(N3CCCCC3)c(C=C3SC(S)=NC3=O)cc2c1 |w:15.15,c:20|
Structure:
Search PDB for entries with ligand similarity: