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Target
Glucose-6-phosphate 1-dehydrogenase
Ligand
BDBM34519
Substrate
n/a
Meas. Tech.
Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase
IC50
37000±n/a nM
Citation
 PubChem, PC Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase PubChem Bioassay (2011)[AID] 
Target
Name:
Glucose-6-phosphate 1-dehydrogenase
Synonyms:
G6PD | G6PD_HUMAN | Glucose 6-phosphate dehydrogenase (G6PD) | Glucose-6-phosphate 1-dehydrogenase | glucose-6-phosphate 1-dehydrogenase isoform b
Type:
Enzyme
Mol. Mass.:
59258.58
Organism:
Homo sapiens (Human)
Description:
P11413
Residue:
515
Sequence:
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
  
Inhibitor
Name:
BDBM34519
Synonyms:
2-[2-keto-2-(4-piperidinopiperidino)ethyl]-4,6-dimethyl-isothiazolo[5,4-b]pyridin-3-one | 4,6-dimethyl-2-[2-oxidanylidene-2-(4-piperidin-1-ylpiperidin-1-yl)ethyl]-[1,2]thiazolo[5,4-b]pyridin-3-one | 4,6-dimethyl-2-[2-oxo-2-(4-piperidin-1-ylpiperidin-1-yl)ethyl]-[1,2]thiazolo[5,4-b]pyridin-3-one | 4,6-dimethyl-2-[2-oxo-2-[4-(1-piperidinyl)-1-piperidinyl]ethyl]-3-isothiazolo[5,4-b]pyridinone | MLS000118880 | SMR000095820 | cid_5309471
Type:
Small organic molecule
Emp. Form.:
C20H28N4O2S
Mol. Mass.:
388.527
SMILES:
Cc1cc(C)c2c(n1)sn(CC(=O)N1CCC(CC1)N1CCCCC1)c2=O
Structure:
Search PDB for entries with ligand similarity: