Reaction Details Report a problem with these data
Target
cAMP-dependent protein kinase type II-beta regulatory subunit
Ligand
BDBM81291
Substrate
n/a
Meas. Tech.
Counterscreen for activators of the Protein Kinase A-R1A (PKA-R1A) complex
EC50
50.49±n/a nM
Citation
 PubChem, PC Counterscreen for activators of the Protein Kinase A-R1A (PKA-R1A) complex: fluorescence polarization-based biochemical high throughput dose response assay to identify activators of the Protein Kinase A-R2B (PKA-R2B) complex PubChem Bioassay (2011)[AID] 
Target
Name:
cAMP-dependent protein kinase type II-beta regulatory subunit
Synonyms:
KAP3_HUMAN | PRKAR2B
Type:
PROTEIN
Mol. Mass.:
46282.41
Organism:
Homo sapiens (Human)
Description:
EBI_11972
Residue:
418
Sequence:
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA
  
Inhibitor
Name:
BDBM81291
Synonyms:
8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate sodium salt | MLS002153200 | SMR000326853 | cid_23672705 | sodium;(4aR,6R,7R,7aS)-6-[6-amino-8-(4-chlorophenyl)sulfanylpurin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol | sodium;(4aR,6R,7R,7aS)-6-[6-amino-8-[(4-chlorophenyl)thio]-9-purinyl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphorin-7-ol | sodium;(4aR,6R,7R,7aS)-6-[6-amino-8-[(4-chlorophenyl)thio]purin-9-yl]-2-keto-2-oxido-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphorin-7-ol | sodium;(4aR,6R,7R,7aS)-6-[6-azanyl-8-(4-chlorophenyl)sulfanyl-purin-9-yl]-2-oxidanidyl-2-oxidanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Type:
Small organic molecule
Emp. Form.:
C16H14ClN5O6PS
Mol. Mass.:
470.805
SMILES:
Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Sc3ccc(Cl)cc3)nc12
Structure:
Search PDB for entries with ligand similarity: