Reaction Details Report a problem with these data
Target
Lanosterol 14-alpha-demethylase
Ligand
BDBM81309
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6±0
Kd
8e+1±n/a nM
Citation
 Lepesheva, GI; Ott, RD; Hargrove, TY; Kleshchenko, YY; Schuster, I; Nes, WD; Hill, GC; Villalta, F; Waterman, MR Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. Chem Biol 14:1283-93 (2007) [PubMed]  Article 
Target
Name:
Lanosterol 14-alpha-demethylase
Synonyms:
Lanosterol 14-alpha demethylase | Sterol 14-alpha demethylase (CYP51)
Type:
Protein
Mol. Mass.:
54377.77
Organism:
Trypanosoma brucei
Description:
Q385E8
Residue:
481
Sequence:
MLLEVAIFLLTALALYSFYFVKSFNVTRPTDPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKEEEVNKDSSTSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVGPTASQCRVKYIRRKAAAA
  
Inhibitor
Name:
BDBM81309
Synonyms:
Azole, 17
Type:
Small organic molecule
Emp. Form.:
C27H27ClN4O2
Mol. Mass.:
474.982
SMILES:
CCCCOc1ccc(cc1)-c1ccc(cc1)C(=O)NC(Cn1ccnc1)c1ccc(Cl)cn1
Structure:
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