Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM81321
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±0
IC50
>3.00e+5±n/a nM
Citation
 King, AR; Duranti, A; Tontini, A; Rivara, S; Rosengarth, A; Clapper, JR; Astarita, G; Geaga, JA; Luecke, H; Mor, M; Tarzia, G; Piomelli, D URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. Chem Biol 14:1357-65 (2007) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL)
Type:
Enzyme
Mol. Mass.:
33505.38
Organism:
Rattus norvegicus (Rat)
Description:
Q8R431
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP
  
Inhibitor
Name:
BDBM81321
Synonyms:
URB602, 3m
Type:
Small organic molecule
Emp. Form.:
C17H19NO4
Mol. Mass.:
301.3371
SMILES:
Cc1cccc(c1)-c1cccc(NC(=O)OC(CO)CO)c1
Structure:
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