Reaction Details Report a problem with these data
Target
Inosine-5-monophosphate dehydrogenase
Ligand
BDBM81327
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
8±0
Temperature
298.15±0 K
IC50
5.9e+3± 7e+2 nM
Citation
 Umejiego, NN; Gollapalli, D; Sharling, L; Volftsun, A; Lu, J; Benjamin, NN; Stroupe, AH; Riera, TV; Striepen, B; Hedstrom, L Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis. Chem Biol 15:70-7 (2008) [PubMed]  Article 
Target
Name:
Inosine-5-monophosphate dehydrogenase
Synonyms:
Inosine-5-monophosphate dehydrogenase (IMPDH)
Type:
Protein
Mol. Mass.:
43277.98
Organism:
Cryptosporidium parvum
Description:
Cryptosporidium parvum Iowa II, Q5CPK7
Residue:
402
Sequence:
SNMGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNNIDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
  
Inhibitor
Name:
BDBM81327
Synonyms:
Tetrahydroquinoxalin analog, J
Type:
Small organic molecule
Emp. Form.:
C16H10N4O5
Mol. Mass.:
338.2744
SMILES:
O=c1[nH]c2ccc(Oc3ccc4[nH]c(=O)c(=O)[nH]c4c3)cc2[nH]c1=O
Structure:
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