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Target
Inosine-5-monophosphate dehydrogenase
Ligand
BDBM81329
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
8±0
Temperature
298.15±0 K
IC50
1.9e+4± 1e+3 nM
Citation
 Umejiego, NN; Gollapalli, D; Sharling, L; Volftsun, A; Lu, J; Benjamin, NN; Stroupe, AH; Riera, TV; Striepen, B; Hedstrom, L Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis. Chem Biol 15:70-7 (2008) [PubMed]  Article 
Target
Name:
Inosine-5-monophosphate dehydrogenase
Synonyms:
Inosine-5-monophosphate dehydrogenase (IMPDH)
Type:
Protein
Mol. Mass.:
43277.98
Organism:
Cryptosporidium parvum
Description:
Cryptosporidium parvum Iowa II, Q5CPK7
Residue:
402
Sequence:
SNMGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNNIDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
  
Inhibitor
Name:
BDBM81329
Synonyms:
N-[(Z)-N-(pyridin-3-yl)carboximidoyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide, K
Type:
Small organic molecule
Emp. Form.:
C15H13N3O3
Mol. Mass.:
283.282
SMILES:
O=C(N\C=N/c1cccnc1)C1COc2ccccc2O1
Structure:
Search PDB for entries with ligand similarity: