Target
Cell division protein FtsZ
Ligand
BDBM81333
Substrate
n/a
Meas. Tech.
Fluorescent Coupled Assay
pH
7.5±0
IC50
4.40e+4± 3.4e+3 nM
Citation
 Läppchen, TPinas, VAHartog, AFKoomen, GJSchaffner-Barbero, CAndreu, JMTrambaiolo, DLöwe, JJuhem, APopov, AVden Blaauwen, T Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites. Chem Biol 15:189-99 (2008) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_AQUAE | ftsZ
Type:
Protein
Mol. Mass.:
40146.54
Organism:
Aquifex aeolicus
Description:
O66809
Residue:
367
Sequence:
MEEFVNPCKIKVIGVGGGGSNAVNRMYEDGIEGVELYAINTDVQHLSTLKVPNKIQIGEKVTRGLGAGAKPEVGEEAALEDIDKIKEILRDTDMVFISAGLGGGTGTGAAPVIAKTAKEMGILTVAVATLPFRFEGPRKMEKALKGLEKLKESSDAYIVIHNDKIKELSNRTLTIKDAFKEVDSVLSKAVRGITSIVVTPAVINVDFADVRTTLEEGGLSIIGMGEGRGDEKADIAVEKAVTSPLLEGNTIEGARRLLVTIWTSEDIPYDIVDEVMERIHSKVHPEAEIIFGAVLEPQEQDFIRVAIVATDFPEEKFQVGEKEVKFKVIKKEEKEEPKEEPKPLSDTTYLEEEEIPAVIRRKNKRLL
  
Inhibitor
Name:
BDBM81333
Synonyms:
ClGTP (4b)
Type:
Small organic molecule
Emp. Form.:
C10H12ClN5O14P3
Mol. Mass.:
554.603
SMILES:
Nc1nc2n([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)C(O)C3O)c(Cl)nc2c(=O)[nH]1 |r|
Structure:
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