Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM81334
Substrate
n/a
Meas. Tech.
Fluorescent Coupled Assay
pH
7.5±0
IC50
5.20e+4± 5.7e+3 nM
Citation
 Läppchen, T; Pinas, VA; Hartog, AF; Koomen, GJ; Schaffner-Barbero, C; Andreu, JM; Trambaiolo, D; Löwe, J; Juhem, A; Popov, AV; den Blaauwen, T Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites. Chem Biol 15:189-99 (2008) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_AQUAE | ftsZ
Type:
Protein
Mol. Mass.:
40146.54
Organism:
Aquifex aeolicus
Description:
O66809
Residue:
367
Sequence:
MEEFVNPCKIKVIGVGGGGSNAVNRMYEDGIEGVELYAINTDVQHLSTLKVPNKIQIGEKVTRGLGAGAKPEVGEEAALEDIDKIKEILRDTDMVFISAGLGGGTGTGAAPVIAKTAKEMGILTVAVATLPFRFEGPRKMEKALKGLEKLKESSDAYIVIHNDKIKELSNRTLTIKDAFKEVDSVLSKAVRGITSIVVTPAVINVDFADVRTTLEEGGLSIIGMGEGRGDEKADIAVEKAVTSPLLEGNTIEGARRLLVTIWTSEDIPYDIVDEVMERIHSKVHPEAEIIFGAVLEPQEQDFIRVAIVATDFPEEKFQVGEKEVKFKVIKKEEKEEPKEEPKPLSDTTYLEEEEIPAVIRRKNKRLL
  
Inhibitor
Name:
BDBM81334
Synonyms:
MeGTP (1b)
Type:
Small organic molecule
Emp. Form.:
C11H15N5O14P3
Mol. Mass.:
534.1848
SMILES:
Cc1nc2c(nc(N)[nH]c2=O)n1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)C(O)C1O |r|
Structure:
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