Reaction Details Report a problem with these data
Target
Methionine aminopeptidase 2
Ligand
BDBM50194623
Substrate
n/a
Meas. Tech.
Enzyme Inhibiton Assay
IC50
>5.00e+5±n/a nM
Citation
 Chen, X; Xie, S; Bhat, S; Kumar, N; Shapiro, TA; Liu, JO Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol 16:193-202 (2009) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
MetAP2 | Methionine aminopeptidase (MetAP2)
Type:
Protein
Mol. Mass.:
40537.47
Organism:
Plasmodium falciparum
Description:
Q8TA23
Residue:
354
Sequence:
MIYGKDGKYPVGEILEYNNYNLSGQSLVEKKEREKLSIDYYEDLRKAAECHRQVRKHMQAFIKPGKKMIDIAQETERKTKELILAEKLKCGWGFPTGCSLNHCAAHYTPNYGDETVLKYDDVCKLDFGVHVNGYIIDCAFTIAFNEKYDNLIKATQDGTNTGIKEAGIDARMCDIGEAIQEAIESYEIELNQKIYPIKAISNLRGHSINKYIIHGGKCVPIVRQKEKNEIMEEGELFAIETFASTGKGYVNHENECSHYMRNPEKQFVPIRLNSAKTLLKVINDNFDTLPFCNRWLDDLGQTRHFMALKTLIDLNIVEPYPPLCDIKNSFTSQMEHTILLRPTCKEVLSRGPDF
  
Inhibitor
Name:
BDBM50194623
Synonyms:
(1S,5S,6R,E)-5-(hydroxymethyl)-1-methoxy-6-(6-methylhepta-2,5-dien-2-yl)bicyclo[3.1.0]hexan-2-one | CHEMBL213526 | Fumarranol Analog, 8
Type:
Small organic molecule
Emp. Form.:
C16H24O3
Mol. Mass.:
264.36
SMILES:
[#6]-[#8][C@@]12[#6](\[#6](-[#6])=[#6]\[#6]\[#6]=[#6](\[#6])-[#6])[C@]1([#6]-[#8])[#6]-[#6]-[#6]2=O
Structure:
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