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Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM81422
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±0
Temperature
298.15±0 K
IC50
1.3e+3±n/a nM
Citation
 Gollapalli, DR; Macpherson, IS; Liechti, G; Gorla, SK; Goldberg, JB; Hedstrom, L Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases. Chem Biol 17:1084-91 (2010) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
Inosine-5-monophosphate dehydrogenase (IMPDH)
Type:
Protein
Mol. Mass.:
51794.42
Organism:
Helicobacter pylori (strain G27)
Description:
B5Z7J4
Residue:
481
Sequence:
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNIRLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHAHKTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLDEASDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDVLVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSICTTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYYG
  
Inhibitor
Name:
BDBM81422
Synonyms:
N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide, Compound B
Type:
Small organic molecule
Emp. Form.:
C19H17NO2
Mol. Mass.:
291.3438
SMILES:
COc1ccc(NC(=O)Cc2cccc3ccccc23)cc1
Structure:
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