Reaction Details Report a problem with these data
Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM81422
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±0
Temperature
298.15±0 K
IC50
1.8e+3±n/a nM
Citation
 Gollapalli, DR; Macpherson, IS; Liechti, G; Gorla, SK; Goldberg, JB; Hedstrom, L Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases. Chem Biol 17:1084-91 (2010) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
IMDH_BORBU | Inosine-5-monophosphate dehydrogenase (IMPDH) | guaB
Type:
Protein
Mol. Mass.:
43775.62
Organism:
Borrelia burgdorferi
Description:
P49058
Residue:
404
Sequence:
MPNKITKEALTFDDVSLIPRKSSVLPSEVSLKTQLTKNISLNIPFLSSAMDTVTESQMAIAIAKEGGIGIIHKNMSIEAQRKEIEKVKTYKFQKTINTNGDTNEQKPEIFTAKQHLEKSDAYKNAEHKEDFPNACKDLNNKLRVGAAVSIDIDTIERVEELVKAHVDILVIDSAHGHSTRIIELIKKIKTKYPNLDLIAGNIVTKEAALDLISVGADCLKVGIGPGSICTTRIVAGVGVPQITAICDVYEACNNTNICIIADGGIRFSGDVVKAIAAGADSVMIGNLFAGTKESPSEEIIYNGKKFKSYVGMGSISAMKRGSKSRYFQLENNEPKKLVPEGIEGMVPYSGKLKDILTQLKGGLMSGMGYLGAATISDLKINSKFVKISHSSLKESHPHDVFSIT
  
Inhibitor
Name:
BDBM81422
Synonyms:
N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide, Compound B
Type:
Small organic molecule
Emp. Form.:
C19H17NO2
Mol. Mass.:
291.3438
SMILES:
COc1ccc(NC(=O)Cc2cccc3ccccc23)cc1
Structure:
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