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Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM81425
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±0
Temperature
298.15±0 K
IC50
1.3e+4±n/a nM
Citation
 Gollapalli, DR; Macpherson, IS; Liechti, G; Gorla, SK; Goldberg, JB; Hedstrom, L Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases. Chem Biol 17:1084-91 (2010) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
IMDH_STRPY | Inosine-5-monophosphate dehydrogenase (IMPDH) | guaB | impD
Type:
Protein
Mol. Mass.:
52801.05
Organism:
Streptococcus pyogenes
Description:
P0C0H6
Residue:
493
Sequence:
MSNWDTKFLKKGYTFDDVLLIPAESHVLPNEVDLKTKLADNLTLNIPIITAAMDTVTGSKMAIAIARAGGLGVIHKNMSITEQAEEVRKVKRSENGVIIDPFFLTPEHKVSEAEELMQRYRISGVPIVETLANRKLVGIITNRDMRFISDYNAPISEHMTSEHLVTAAVGTDLETAERILHEHRIEKLPLVDNSGRLSGLITIKDIEKVIEFPHAAKDEFGRLLVAAAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPNRTLIAGNIATAEGARALYDAGVDVVKVGIGPGSICTTRVVAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIYQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAASDIVFQMLGGIRSGMGYVGAGDIQELHENAQFVEMSGAGLIESHPHDVQITNEAPNYSVH
  
Inhibitor
Name:
BDBM81425
Synonyms:
l-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)-N-(4-methoxyphenyl)acetamide, Compound F
Type:
Small organic molecule
Emp. Form.:
C17H17N3O3S2
Mol. Mass.:
375.465
SMILES:
CCn1c(SCC(=O)Nc2ccc(OC)cc2)nc2ccsc2c1=O
Structure:
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