Reaction Details
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Sentrin-specific protease 7
Ligand
BDBM81517
Substrate
n/a
Meas. Tech.
Fluorogenic Assay
pH
8±0
Temperature
310.15±0 K
IC50
4.3e+3± 7e+2 nM
Citation
Albrow, VE; Ponder, EL; Fasci, D; Békés, M; Deu, E; Salvesen, GS; Bogyo, M Development of small molecule inhibitors and probes of human SUMO deconjugating proteases. Chem Biol 18:722-32 (2011) [PubMed] Article More Info.:
Target
Name:
Sentrin-specific protease 7
Synonyms:
KIAA1707 | SENP7 | SENP7_HUMAN | SSP2 | SUSP2 | Sentrin-specific protease 7 (SENP7)
Type:
Protein
Mol. Mass.:
119657.39
Organism:
Homo sapiens (Human)
Description:
Q9BQF6
Residue:
1050
Sequence:
MDKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLPLQWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRNDANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERIPRVILTNVLGTELGRKYIRTPPVTEGSLSDTDNLQSEQLSSSSDGSLESYQNLNPHKSCYLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESALLELPLITCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKIKGASKGCVTITKKYIKIPFQVSLNEISLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQEIQTQLEHSVLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELSYPLSWVQAFPLFQNLSSKESSFIHYYCVSTCSFPAGVAVAEEMKLKSVSQPSNTDAAKPTYTFLQKQSSGCYSLSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTIDNDLRTTSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEVEWEVKLKTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEKWFPRHVIKTKREDIRELILKLHLQQQKGSSS
Inhibitor
Name:
BDBM81517
Synonyms:
VEA-561
Type:
Small organic molecule
Emp. Form.:
C40H46N8O10
Mol. Mass.:
798.8408
SMILES:
[#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6]-c1ccc(-[#8])c(c1)N(=O)=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#6]-[#8]-[#6](=O)-c1c2ccccc2cc2ccccc12 |r|
Structure:
