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Target
Cyclin-dependent kinase 2
Ligand
BDBM27216
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
pH
7.4±0
Temperature
277.15±0 K
IC50
7e+1±n/a nM
Citation
 Dalgarno, D; Stehle, T; Narula, S; Schelling, P; van Schravendijk, MR; Adams, S; Andrade, L; Keats, J; Ram, M; Jin, L; Grossman, T; MacNeil, I; Metcalf, C; Shakespeare, W; Wang, Y; Keenan, T; Sundaramoorthi, R; Bohacek, R; Weigele, M; Sawyer, T Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds. Chem Biol Drug Des 67:46-57 (2006) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM27216
Synonyms:
(2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)-3-methylbutan-1-ol | 2,6,9-Trisubstitute purine, 1 | CHEMBL23327 | Purvalanol A
Type:
Small organic molecule
Emp. Form.:
C19H25ClN6O
Mol. Mass.:
388.894
SMILES:
CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1
Structure:
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