Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2
Ligand
BDBM50314074
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
pH
7.4±0
Temperature
277.15±0 K
IC50
2.09e+4±n/a nM
Citation
Dalgarno, D; Stehle, T; Narula, S; Schelling, P; van Schravendijk, MR; Adams, S; Andrade, L; Keats, J; Ram, M; Jin, L; Grossman, T; MacNeil, I; Metcalf, C; Shakespeare, W; Wang, Y; Keenan, T; Sundaramoorthi, R; Bohacek, R; Weigele, M; Sawyer, T Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds. Chem Biol Drug Des 67:46-57 (2006) [PubMed] Article
More Info.:
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Inhibitor
Name:
BDBM50314074
Synonyms:
2,6,9-Trisubstitute purine, 6 (AP23464) | 3-(2-(2-cyclopentyl-6-(4-(dimethylphosphoryl)phenylamino)-9H-purin-9-yl)ethyl)phenol | 3-[2-(2-CYCLOPENTYL-6-{[4-(DIMETHYLPHOSPHORYL)PHENYL]AMINO}-9H-PURIN-9-YL)ETHYL]PHENOL | AP-23464 | CHEMBL1089405
Type:
Small organic molecule
Emp. Form.:
C26H30N5O2P
Mol. Mass.:
475.5225
SMILES:
CP(C)(=O)c1ccc(Nc2nc(nc3n(CCc4cccc(O)c4)cnc23)C2CCCC2)cc1