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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM81720
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
1010±0.0 nM
Citation
 Shakespeare, WC; Wang, Y; Bohacek, R; Keenan, T; Sundaramoorthi, R; Metcalf, C; Dilauro, A; Roeloffzen, S; Liu, S; Saltmarsh, J; Paramanathan, G; Dalgarno, D; Narula, S; Pradeepan, S; van Schravendijk, MR; Keats, J; Ram, M; Liou, S; Adams, S; Wardwell, S; Bogus, J; Iuliucci, J; Weigele, M; Xing, L; Boyce, B; Sawyer, TK SAR of carbon-linked, 2-substituted purines: synthesis and characterization of AP23451 as a novel bone-targeted inhibitor of Src tyrosine kinase with in vivo anti-resorptive activity. Chem Biol Drug Des 71:97-105 (2008) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Neuronal proto-oncogene tyrosine-protein kinase Src | Proto-oncogene c-Src | SRC_MOUSE | Src | Tyrosine-protein kinase SRC
Type:
Protein
Mol. Mass.:
60650.57
Organism:
Mus musculus (Mouse)
Description:
P05480
Residue:
541
Sequence:
MGSNKSKPKDASQRRRSLEPSENVHGAGGAFPASQTPSKPASADGHRGPSAAFVPPAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM81720
Synonyms:
2,6,9-Trisubstituted Purine, 6
Type:
Small organic molecule
Emp. Form.:
C21H30N6O5P2
Mol. Mass.:
508.4476
SMILES:
CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(CCC3CCNCC3)nc12
Structure:
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