Reaction Details
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5-hydroxytryptamine receptor 2A
Ligand
BDBM50017452
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_1240
Citation
Roth, BL; Ciaranello, RD; Meltzer, HY Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors. J Pharmacol Exp Ther 260:1361-5 (1992) [PubMed] More Info.:
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
Inhibitor
Name:
BDBM50017452
Synonyms:
2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl | 6'-Chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl(MK-212) | CHEMBL269521 | L-630,571 | MK 212 | MK-212
Type:
Small organic molecule
Emp. Form.:
C8H11ClN4
Mol. Mass.:
198.653
SMILES:
Clc1cncc(n1)N1CCNCC1
Structure:
