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Target
Alpha-2C adrenergic receptor
Ligand
BDBM35256
Substrate
n/a
Ki
40±n/a nM
Comments
PDSP_1235
Citation
 Neve, KA; Henningsen, RA; Kinzie, JM; De Paulis, T; Schmidt, DE; Kessler, RM; Janowsky, A Sodium-dependent isomerization of dopamine D-2 receptors characterized using [125I]epidepride, a high-affinity substituted benzamide ligand. J Pharmacol Exp Ther 252:1108-16 (1990) [PubMed] 
Target
Name:
Alpha-2C adrenergic receptor
Synonyms:
ADA2C_RAT | Adra2c | Adrenergic receptor alpha | Alpha-2C adrenergic receptor | adrenergic Alpha2 | adrenergic Alpha2C
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49890.50
Organism:
RAT
Description:
adrenergic Alpha2 0 RAT::P22086
Residue:
458
Sequence:
MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
  
Inhibitor
Name:
BDBM35256
Synonyms:
(S)-mianserin | Lerivon | MIANSERIN | MIANSERIN (+) | MIANSERIN (-) | Tolvon
Type:
Small organic molecule
Emp. Form.:
C18H20N2
Mol. Mass.:
264.3648
SMILES:
[H][C@]12CN(C)CCN1c1ccccc1Cc1ccccc21 |r|
Structure:
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