Reaction Details Report a problem with these data
Target
Free fatty acid receptor 2
Ligand
BDBM271057
Substrate
n/a
Meas. Tech.
Ca-Flux Functional Assay
EC50
6.00±n/a nM
Citation
 Barker, G; Davenport, R; Downham, R; Farnaby, W; Goldby, A; Hannah, D; Harrison, D; Willems, H 3-substituted 2-amino-indole derivatives US Patent  US10059713 Publication Date 8/28/2018 
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43
Type:
PROTEIN
Mol. Mass.:
37156.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508993
Residue:
330
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
  
Inhibitor
Name:
BDBM271057
Synonyms:
7-(2-fluorobenzenesulfonyl)-2-methyl-4-{6-oxa-9-azaspiro[4.5]decan-9-yl}-5H-pyrrolo[3,2-d]pyrimidin-6-amine | US10059713, Example 177
Type:
Small organic molecule
Emp. Form.:
C21H24FN5O3S
Mol. Mass.:
445.51
SMILES:
Cc1nc(N2CCOC3(CCCC3)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
Structure:
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