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TargetLeucyl-cystinyl aminopeptidase
LigandBDBM271187
Substrate/Competitorn/a
Meas. Tech.Inhibition of IRAP Assay
IC50 1.60±n/a nM
Citation Kawaguchi, KIshihata, AInagaki, YTsuchiya, KHanadate, TKanai, AKaizawa, HKazami, JMorikawa, HHiramoto, MEnjo, KTakamatsu, H Pyridine derivative US Patent US10059720 Publication Date 8/28/2018
More Info.:Get all data from this article,  Assay Method
 
Leucyl-cystinyl aminopeptidase
Name:Cystinyl aminopeptidase
Synonyms:Cystinyl aminopeptidase | GP160 | IRAP | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | Irap | Lnpep | OTase | Otase | Oxytocinase | P-LAP | Placental leucine aminopeptidase | Vesicle protein of 165 kDa | Vp165
Type:PROTEIN
Mol. Mass.:117179.39
Organism:Rattus norvegicus
Description:ChEMBL_98523
Residue:1025
Sequence:
METFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMDEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGTCSVPSARTLVICVFVIVV
AVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELS
LHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQVEILEYPYH
EQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAAR
SAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYLVA
FIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWW
NDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKT
LDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVT
DGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNP
YVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLE
KLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMAT
KLFDGWMASNGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASS
ADAHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGS
YTIQSIVAGSTHLFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKT
LTLWL
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  Blast E-value cutoff:
BDBM271187
NameBDBM271187
Synonyms:US10059720, Example 3
TypeSmall organic molecule
Emp. Form.C19H30N2O4
Mol. Mass.350.4525
SMILESCC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Structure
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