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TargetLeucyl-cystinyl aminopeptidase
LigandBDBM271210
Substrate/Competitorn/a
Meas. Tech.Inhibition of Human P-LAP (hP-LAP) Assay
IC50 1.80±n/a nM
Citation Kawaguchi, KIshihata, AInagaki, YTsuchiya, KHanadate, TKanai, AKaizawa, HKazami, JMorikawa, HHiramoto, MEnjo, KTakamatsu, H Pyridine derivative US Patent US10059720 Publication Date 8/28/2018
More Info.:Get all data from this article,  Assay Method
 
Leucyl-cystinyl aminopeptidase
Name:Aminopeptidase
Synonyms:Cystinyl aminopeptidase | IRAP | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | Leucyl-cystinyl aminopeptidase, pregnancy serum form | OTase | Oxytocinase | P-LAP | Placental leucine aminopeptidase
Type:PROTEIN
Mol. Mass.:117334.10
Organism:Homo sapiens (Human)
Description:ChEMBL_1473494
Residue:1025
Sequence:
MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV
AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS
LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH
GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR
SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW
NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT
LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT
EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP
YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE
KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM
KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS
EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS
YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS
LTWWL
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  Blast E-value cutoff:
BDBM271210
NameBDBM271210
Synonyms:US10059720, Example 25
TypeSmall organic molecule
Emp. Form.C21H33N3O3
Mol. Mass.375.505
SMILESCCCCCCn1ccc2cnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)cc12 |r|
Structure
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