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TargetLeucyl-cystinyl aminopeptidase
LigandBDBM271246
Substrate/Competitorn/a
Meas. Tech.Inhibition of IRAP Assay
IC50 1.90±n/a nM
Citation Kawaguchi, KIshihata, AInagaki, YTsuchiya, KHanadate, TKanai, AKaizawa, HKazami, JMorikawa, HHiramoto, MEnjo, KTakamatsu, H Pyridine derivative US Patent US10059720 Publication Date 8/28/2018
More Info.:Get all data from this article,  Assay Method
 
Leucyl-cystinyl aminopeptidase
Name:Cystinyl aminopeptidase
Synonyms:Cystinyl aminopeptidase | GP160 | IRAP | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | Irap | Lnpep | OTase | Otase | Oxytocinase | P-LAP | Placental leucine aminopeptidase | Vesicle protein of 165 kDa | Vp165
Type:PROTEIN
Mol. Mass.:117179.39
Organism:Rattus norvegicus
Description:ChEMBL_98523
Residue:1025
Sequence:
METFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMDEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGTCSVPSARTLVICVFVIVV
AVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELS
LHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQVEILEYPYH
EQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAAR
SAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYLVA
FIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWW
NDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKT
LDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVT
DGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNP
YVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLE
KLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMAT
KLFDGWMASNGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASS
ADAHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGS
YTIQSIVAGSTHLFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKT
LTLWL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM271246
NameBDBM271246
Synonyms:US10059720, Example 61
TypeSmall organic molecule
Emp. Form.C22H34N2O5
Mol. Mass.406.5158
SMILESCC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@]3(CCCO3)CC2)ccn1)C(O)=O |r,wU:6.7,13.12,4.4,16.20,wD:6.6,(-7.85,-2.93,;-6.52,-3.7,;-6.52,-5.24,;-5.19,-2.93,;-3.85,-3.7,;-3.85,-5.24,;-2.52,-2.93,;-1.75,-1.6,;-1.18,-3.7,;.15,-2.93,;.15,-1.39,;1.48,-.62,;1.48,.92,;2.82,1.69,;2.82,3.23,;4.15,4,;5.48,3.23,;6.95,2.75,;7.85,4,;6.95,5.24,;5.48,4.77,;5.48,1.69,;4.15,.92,;2.82,-1.39,;2.82,-2.93,;1.48,-3.7,;-3.29,-1.6,;-4.83,-1.6,;-2.52,-.27,)|
Structure
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