Reaction Details Report a problem with these data
Target
Leucyl-cystinyl aminopeptidase
Ligand
BDBM271269
Substrate
n/a
Meas. Tech.
Inhibition of Human P-LAP (hP-LAP) Assay
IC50
3.70±n/a nM
Citation
Kawaguchi, K; Ishihata, A; Inagaki, Y; Tsuchiya, K; Hanadate, T; Kanai, A; Kaizawa, H; Kazami, J; Morikawa, H; Hiramoto, M; Enjo, K; Takamatsu, H Pyridine derivative US Patent US10059720 Publication Date 8/28/2018
More Info.:
Target
Name:
Leucyl-cystinyl aminopeptidase
Synonyms:
Aminopeptidase | Aminopeptidase (P-LAP) | Cystinyl aminopeptidase | IRAP | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | LCAP_HUMAN | LNPEP | Leucyl-cystinyl aminopeptidase, pregnancy serum form | OTASE | Oxytocinase | P-LAP | Placental leucine aminopeptidase
Type:
PROTEIN
Mol. Mass.:
117334.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473494
Residue:
1025
Sequence:
MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL
Inhibitor
Name:
BDBM271269
Synonyms:
US10059720, Example 84 | US10975091, Example 84
Type:
Small organic molecule
Emp. Form.:
C22H28FN3O5
Mol. Mass.:
433.4732
SMILES:
C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)COc2ccc(F)cn2)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(9.34,4.62,;8,3.85,;8,2.31,;6.67,1.54,;5.33,2.31,;5.33,3.85,;6.67,4.62,;4,1.54,;4,,;5.33,-.77,;5.33,-2.31,;4,-3.08,;2.67,-2.31,;1.33,-3.08,;,-2.31,;.77,-.98,;-1.33,-3.08,;-1.33,-4.62,;-2.67,-2.31,;-4,-3.08,;-5.33,-2.31,;-5.33,-.77,;-6.67,,;-8,-.77,;-9.34,,;-8,-2.31,;-6.67,-3.08,;-.77,-.98,;,.36,;-2.31,-.98,;2.67,-.77,)|