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TargetLeucyl-cystinyl aminopeptidase
LigandBDBM271310
Substrate/Competitorn/a
Meas. Tech.Inhibition of IRAP Assay
IC50 0.900±n/a nM
Citation Kawaguchi, KIshihata, AInagaki, YTsuchiya, KHanadate, TKanai, AKaizawa, HKazami, JMorikawa, HHiramoto, MEnjo, KTakamatsu, H Pyridine derivative US Patent US10059720 Publication Date 8/28/2018
More Info.:Get all data from this article,  Assay Method
 
Leucyl-cystinyl aminopeptidase
Name:Cystinyl aminopeptidase
Synonyms:Cystinyl aminopeptidase | GP160 | IRAP | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | Irap | Lnpep | OTase | Otase | Oxytocinase | P-LAP | Placental leucine aminopeptidase | Vesicle protein of 165 kDa | Vp165
Type:PROTEIN
Mol. Mass.:117179.39
Organism:Rattus norvegicus
Description:ChEMBL_98523
Residue:1025
Sequence:
METFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMDEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGTCSVPSARTLVICVFVIVV
AVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELS
LHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQVEILEYPYH
EQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAAR
SAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYLVA
FIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWW
NDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKT
LDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVT
DGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNP
YVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLE
KLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMAT
KLFDGWMASNGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASS
ADAHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGS
YTIQSIVAGSTHLFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKT
LTLWL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM271310
NameBDBM271310
Synonyms:US10059720, Example 125
TypeSmall organic molecule
Emp. Form.C20H31FN2O4
Mol. Mass.382.4695
SMILESC[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)F)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(7.34,4.62,;6,3.85,;6,2.31,;4.67,1.54,;3.33,2.31,;3.33,3.85,;4.67,4.62,;2,1.54,;2,,;3.33,-.77,;3.33,-2.31,;2,-3.08,;.67,-2.31,;-.67,-3.08,;-2,-2.31,;-1.23,-.98,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-2.31,;-6,-3.08,;-7.34,-2.31,;-6,-4.62,;-7.34,-3.85,;-2.77,-.98,;-2,.36,;-4.26,-1.37,;.67,-.77,)|
Structure
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