Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetLeucyl-cystinyl aminopeptidase
LigandBDBM271330
Substrate/Competitorn/a
Meas. Tech.Inhibition of Human P-LAP (hP-LAP) Assay
IC50 1.30±n/a nM
Citation Kawaguchi, KIshihata, AInagaki, YTsuchiya, KHanadate, TKanai, AKaizawa, HKazami, JMorikawa, HHiramoto, MEnjo, KTakamatsu, H Pyridine derivative US Patent US10059720 Publication Date 8/28/2018
More Info.:Get all data from this article,  Assay Method
 
Leucyl-cystinyl aminopeptidase
Name:Aminopeptidase
Synonyms:Cystinyl aminopeptidase | IRAP | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | Leucyl-cystinyl aminopeptidase, pregnancy serum form | OTase | Oxytocinase | P-LAP | Placental leucine aminopeptidase
Type:PROTEIN
Mol. Mass.:117334.10
Organism:Homo sapiens (Human)
Description:ChEMBL_1473494
Residue:1025
Sequence:
MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV
AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS
LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH
GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR
SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW
NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT
LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT
EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP
YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE
KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM
KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS
EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS
YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS
LTWWL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM271330
NameBDBM271330
Synonyms:US10059720, Example 145
TypeSmall organic molecule
Emp. Form.C20H32N2O4S
Mol. Mass.396.544
SMILESCCCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:7.8,5.5,17.17,wD:7.7,14.13,(-8.67,-2.31,;-7.34,-3.08,;-6,-2.31,;-4.67,-3.08,;-3.33,-2.31,;-2,-3.08,;-2,-4.62,;-.67,-2.31,;.1,-.98,;.67,-3.08,;2,-2.31,;2,-.77,;3.33,,;3.33,1.54,;4.67,2.31,;6,1.54,;7.34,2.31,;7.34,3.85,;8.67,4.62,;6,4.62,;4.67,3.85,;4.67,-.77,;4.67,-2.31,;3.33,-3.08,;-1.44,-.98,;-2.92,-1.37,;-.67,.36,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a