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Target
cGMP-dependent protein kinase 1
Ligand
BDBM3040
Substrate
Histone II-A
Meas. Tech.
cGPK assay
IC50
220±n/a nM
Citation
 Kleinschroth, J; Hartenstein, J; Rudolph, C; Schachtele, C Novel Indolocarbazole protein kinase C inhibitors with improved biochemical and physicochemical properties. Bioorg Med Chem Lett 5:55-60 (1995)    Article 
Target
Name:
cGMP-dependent protein kinase 1
Synonyms:
CGK 1 alpha | KGP1_BOVIN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | cGMP-Dependent Protein Kinase | cGMP-dependent protein kinase 1 alpha | cGMP-dependent protein kinase 1, alpha isozyme
Type:
Enzyme
Mol. Mass.:
76413.14
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
671
Sequence:
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPNEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF
  
Inhibitor
Name:
BDBM3040
Synonyms:
23-(3-aminopropyl)-3-methyl-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4,6,8,11(15),17(22),18,20-nonaen-12-one | Indolocarbazole deriv. 3h
Type:
Small organic molecule
Emp. Form.:
C24H22N4O
Mol. Mass.:
382.4577
SMILES:
Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCCN)c3c12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Histone II-A
Synonyms:
n/a
Type:
Other Protein Type
Mol. Mass.:
358.43
Organism:
n/a
Description:
Unfractionated whole histone. 10 uM ATP (0.3 uCi [gamma-32P]ATP) as co-substrate.
Residue:
3
Sequence:
NA