Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM82114
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
9.4±0.0 nM
Citation
 Ma, X; Woon, RS; Ho, PC; Chui, WK Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates. Chem Biol Drug Des 74:322-6 (2009) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR)
Type:
Enzyme
Mol. Mass.:
21603.71
Organism:
Bos taurus (Cattle)
Description:
P00376
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSSVYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKFEVYEKNN
  
Inhibitor
Name:
BDBM82114
Synonyms:
1,3,5-Triazaspiro[5.5]undeca-1,3-diene-2,4-diamine, IIc
Type:
Small organic molecule
Emp. Form.:
C16H23N5O
Mol. Mass.:
301.3867
SMILES:
NC1=NC2(CCCCC2)N(OCCc2ccccc2)C(N)=N1 |c:22,t:1|
Structure:
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