Target
Phosphopantetheine adenylyltransferase
Ligand
BDBM82147
Substrate
n/a
Meas. Tech.
Reverse PPAT Assay
IC50
>2.30e+5±n/a nM
Citation
 Miller, JRThanabal, VMelnick, MMLall, MDonovan, CSarver, RWLee, DYOhren, JEmerson, D The use of biochemical and biophysical tools for triage of high-throughput screening hits - A case study with Escherichia coli phosphopantetheine adenylyltransferase. Chem Biol Drug Des 75:444-54 (2010) [PubMed]  Article 
Target
Name:
Phosphopantetheine adenylyltransferase
Synonyms:
COAD_ECOLI | Dephospho-CoA pyrophosphorylase | Pantetheine-phosphate adenylyltransferase | Phosphopantetheine adenylyltransferase (PPAT) | coaD | kdtB | yicA
Type:
Protein
Mol. Mass.:
17838.96
Organism:
Escherichia coli
Description:
P0A6I6
Residue:
159
Sequence:
MQKRAIYPGTFDPITNGHIDIVTRATQMFDHVILAIAASPSKKPMFTLEERVALAQQATAHLGNVEVVGFSDLMANFARNQHATVLIRGLRAVADFEYEMQLAHMNRHLMPELESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPENVHQALMAKLA
  
Inhibitor
Name:
BDBM82147
Synonyms:
7-substituted pyrazoloquinolone, 6
Type:
Small organic molecule
Emp. Form.:
C11H7N3O3
Mol. Mass.:
229.1916
SMILES:
OC(=O)c1cc2nc3ccccc3c(=O)n2[nH]1
Structure:
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