Reaction Details
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Substance-K receptor
Ligand
BDBM82263
Substrate
n/a
Ki
41±n/a nM
Comments
PDSP_565
Citation
Aharony, D; Buckner, CK; Ellis, JL; Ghanekar, SV; Graham, A; Kays, JS; Little, J; Meeker, S; Miller, SC; Undem, BJ Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity. J Pharmacol Exp Ther 274:1216-21 (1995) [PubMed] More Info.:
Target
Name:
Substance-K receptor
Synonyms:
NK2R_MESAU | Neurokinin 2 receptor | Neurokinin NK2 | TAC2R | TACR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43436.75
Organism:
HAMSTER
Description:
P51144
Residue:
384
Sequence:
MGGRAIVTDTNIFSGLESNTTGVTAFSMPAWQLALWATAYLGLVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPITKATIAGIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHLVVFVLVYFLPLVVMFVAYSVIGLTLWKRAVPRHQAHGANLRHLHAKKKFVKAMVLVVLTFAICWLPYHLYFILGSFQKDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTRTPSLSRRVNRCHTKETLFMTADMTHSEATNGQVGSPQDVEPAAP
Inhibitor
Name:
BDBM82263
Synonyms:
COMPOUND II
Type:
n/a
Emp. Form.:
C22H27ClN6O3
Mol. Mass.:
458.941
SMILES:
Clc1ccc(Nc2nc(nc3C(=O)N(CCN4CCOCC4)Cc23)N2CCOCC2)cc1
Structure:
